镁合金表面可降解聚合物改性涂层研发及应用

相比于钛合金、不锈钢、钴基合金等传统生物医用金属材料,镁合金不仅具有生物可降解特性,而且其弹性模量与人体骨骼很接近,不容易产生“应力屏蔽”,被誉为“新一代先进生物材料”。但镁合金在人体降解速率过快,由此产生的力学失稳和过量降解产物在体内的代谢吸收隐患限制了其在外科植介入医疗领域的大量推广应用。而可生物降解或可吸收的天然和合成高分子(聚合物)是全球量大面广的一类质轻、多功效、生物安全性好的生物医用材料,若将其作为可降解镁合金表面的特种防护涂层并解决好两者表界面之间的生物功能性和力学相容性,将是开发先进镁合金材料及其应用的重要发展方向。本文综述了生物可降解的镁基合金表面天然及合成高分子涂层的最新研究进展,并对其未来的研发及应用发展趋势提出展望。

Development and application of degradable polymer modified coating on magnesium alloy surface

Compared with traditional biomedical metal materials, such as titanium alloys, stainless steels, cobalt-base alloys, magnesium alloys not only possess biodegradable properties, but also its elastic modulus is close to human bone, so it is hard to induce the effect of ing", so it is known as "new generation of advanced biomaterials". However, the degradation rate of magnesium alloy in human body is too fast, resulting in mechanical instability and metabolic absorption of excessive degradation products in vivo, which limits its application in the field of surgical implant and intervention. Biodegradable or absorbable natural and synthetic polymers are a kind of biomedical materials with light weight, multi-function and good biological safety. If they are used as special protective coating on the surface of degradable magnesium alloys and deal well with the biological function and mechanical compatibility of surfaces between them, it will be important direction to develop advanced magnesium alloys materials and their applications. In this paper, the latest research progress of biodegradable natural and synthetic polymer coatings on magnesium based alloys is reviewed, and the development trend of its research and development and application in the future is put forward.