元胡止痛栓镇痛作用的实验研究

目的:探讨元胡止痛栓的镇痛作用。方法:使用小鼠热板法、大鼠甲醛法, 并分别建立小鼠、大鼠痛经模型, 直肠给予不同剂量元胡止痛栓, 观察对动物的镇痛作用。取雌性大鼠离体子宫, 分别于浴槽中加入不同剂量的元胡止痛栓原料药, 观察对大鼠离体子宫收缩频率、幅度、活动力的影响。结果:元胡止痛栓能提高小鼠热板法、大鼠甲醛法动物的痛阈;延长小鼠、大鼠痛经模型的扭体潜伏期、降低扭体次数及扭体发生率;对大鼠离体子宫自发活动的幅度降低较小, 可减少自发活动的频率及降低活动力, 对催产素所致离体子宫平滑肌收缩的频率减少较小, 但降低收缩幅度, 减弱离体子宫平滑肌的活动力较为显著。结论:元胡止痛栓具有较好的镇痛作用, 并能对抗催产素所致离体子宫平滑肌的收缩作用。

Experimental study on analgesic efficacy of Corydalis suppositories

AIM: To investigate the analgesic efficacy of Corydalis suppositories.METHODS: Rats and mice aching models given different doses of Corydalis suppositories by rectum were established to observe the analgesic efficacy;the influence of the Corydalis suppositories was recorded on the frequency, range andmotoricity of uterine smooth muscle in vitro.RESULTS: Compared to control group, Corydalis suppositories enhanced pain threshold, delayed latent period, decreased mumber of times and twisting bodies incidence of animals, and weakened frequency, range and motoricity of uterine smooth muscle in vitro induced by pitocin.CONCLUSION: Corydalis suppositories can relieve the pain of various aching models and resists the acute contraction induced by oxytocin.