| 快中子诱发U251神经胶质瘤细胞的生物效应研究 |
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| 引用本文： | 杨磊,王潇,孔福全.快中子诱发U251神经胶质瘤细胞的生物效应研究[J].中国工程科学,2012,14(8):91-95. |
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| 作者姓名： | 杨磊 王潇 孔福全 |
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| 作者单位： | 中国原子能科学研究院,北京,102413 |
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| 基金项目： | 国家自然科学基金(11079054)。 |
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| 摘 要： | 目的:以14 MeV快中子照射体外培养的U251(人脑胶质瘤)细胞,研究快中子诱发U251的相关生物效应;方法:快中子照射U251细胞,吸收剂量分别为1、3、5、7 Gy,辐照后检测细胞的存活率、凋亡率、生长曲线以及周期变化等相关指标;结果:随着吸收剂量的增加,细胞存活率下降,凋亡率上升,呈良好的剂量-效应关系.照射后24h,细胞生长曲线无明显变化;照射后48 h,细胞增殖速度明显变缓;结论:快中子为高LET射线,与相关文献报道的γ射线相比,快中子具有较高的相对生物效应.
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| 关 键 词： | 快中子 U251细胞 生物效应 剂量效应曲线 |
| 收稿时间： | 2012/5/15 0:00:00 |
| 修稿时间： | 6/18/2012 2:15:22 PM |
A biological effectiveness study on U251 induced by fast neutrons |
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| Yang Lei,Wang Xiao and Kong Fuquan.A biological effectiveness study on U251 induced by fast neutrons[J].Engineering Science,2012,14(8):91-95. |
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| Authors: | Yang Lei Wang Xiao and Kong Fuquan |
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| Affiliation: | (China Institute of Atomic Energy,Beijing 102413,China) |
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| Abstract: | Objective: U251 cells were exposed to fast neutrons of 14 MeV energy,and dose-response relationships were derived;Methods:cell samples were exposed to fast neutrons.Radiation doses were 1 Gy,3 Gy,5 Gy and 7 Gy respectively.The cell survival,apoptotic rate and proliferation were tested after irradiation;Result: with the growth of the radiation dose,cell survival was declined,and apoptotic rate was promoted;the speed of the cell proliferation,which was observed 48 h after irradiation,was slowed down obviously;Conclusion: compared to γ ray,fast neutrons have higher relative biological effectiveness. |
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| Keywords: | fast neutron U251 cell biological effectiveness dose respond curve |
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