纳米复合支架结构与生物学性能

通过复合成型致孔一体技术制备纳米羟基磷灰石/聚酰胺66 (n-HA/PA66) 硬组织修复支架,采用SEM、XRD、IR和燃烧实验等测试手段对复合支架进行表征。结果表明:n-HA粒子以纳米尺度均匀分布于复合支架材料中;复合材料的两相界面为氢键键合和配位键合;支架的孔隙相互贯通,不仅有平均孔径约450 μ m的大孔,大孔壁上还富含0.5~50 μ m的微孔。动物实验证实,该纳米复合支架具有高的生物活性和好的组织相容性,能与硬组织形成骨性结合,其孔隙范围有利于骨组织、血管、骨细胞的长入,可作为硬组织修复的良好载体。

STRUCTURE AND BIOLOGIC PROPERTIES OF NANO-COMPOSITE SCAFFOLD

A method was investigated for preparing bioactive n-HA (nano-hydroxyapatite) and PA66 (Polyamide 66) nano-composite as the scaffold for the hard tissue repair using integrating composite with mold and pore. SEM, XRD, IR and burning test were used to analyze the physical and chemical properties of the scaffold. The results indicate that n-HA particles disperse with nano scale in the composite; there are hydrogen bonding and ligand bonding between HA and PA; the scaffold has three-dimensional pored structure with 450μm macropores and 0.5~50μm micropores. Animal testing shows that there are good histological compatibility and high bioactivity between the porous scaffold and bone. The scaffold is a kind of excellent carriers for bone repair because it produces bone-bonding with host and implant and its different pore sizes are beneficial to the growth of bone tissue, blood vessels and osteocytes.