| 快速检测糖化血红蛋白的免疫微传感器 |
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| 引用本文： | 边超,屈岚,薛茜男,孙楫舟,张虹,夏善红.快速检测糖化血红蛋白的免疫微传感器[J].纳米技术与精密工程,2010,8(1):20-24. |
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| 作者姓名： | 边超 屈岚 薛茜男 孙楫舟 张虹 夏善红 |
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| 作者单位： | 中国科学院电子学研究所传感技术联合国家重点实验室,北京,100190 |
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| 基金项目： | 国家高技术研究发展计划(863)资助项目(2006AA04Z366);;国家自然科学基金资助项目(60672019);;中国科学院知识创新工程重要方向项目(KGCX2-YW-111-6) |
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| 摘 要： | 研制基于标准CM05工艺和微加工技术的微型糠化血红蛋白免疫传感器，可用于血液中糖化血红蛋白浓度与血红蛋白浓度的快速检测．该微传感器包括含有信号读出电路的传感集成芯片和一次性测试试条，实现了对4—24μg/mL糖化血红蛋白和60～180μg/mL血红蛋白的检测，响应时间小于3min，试剂用量10μL，具有简便、快速、试剂用量少等优点．
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| 关 键 词： | CMOS 微加工 糖化血红蛋白 集成芯片 |
Micro Immunosensor for Rapid Detection of Glycated Hemoglobin |
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| BIAN Chao,QU Lan,XUE Qian-nan,SUN Ji-zhou,ZHANG Hong,XIA Shan-hong.Micro Immunosensor for Rapid Detection of Glycated Hemoglobin[J].Nanotechnology and Precision Engineering,2010,8(1):20-24. |
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| Authors: | BIAN Chao QU Lan XUE Qian-nan SUN Ji-zhou ZHANG Hong XIA Shan-hong |
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| Affiliation: | State Key Laboratory of Transducer Technology/a>;Institute of Electronics/a>;Chinese Academy of Sciences/a>;Beijing 100190/a>;China |
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| Abstract: | A miniaturized immunosensor based on the standard CMOS process and micro fabrication technique was developed,which can achieve rapid detection of the concentrations of glycated hemoglobin (HbAlc) and hemoglobin in blood.This immunosensor consists of a micro sensor chip integrated with signal readout circuit and a disposable probe electrode.HbAlc from 4 to 24 μg/mL and hemoglobin from 60 to 180 μg/mL can be detected by this immunosensor,with response time within 3 min and reagent consumption of only 10 μL.This sensor has the advantages of simple operation,rapid response and less reagent consumption. |
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| Keywords: | CMOS CMOS micro fabrication glycated hemoglobin (HbAlc) integrated chip |
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