Nanodispersions stabilized by β-cyclodextrin nanosponges: application for simultaneous enhancement of bioactivity and stability of sage essential oil |
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| Authors: | Yacine Nait Bachir Ryma Nait Bachir Amel Hadj-Ziane-Zafour |
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| Affiliation: | 1. Chemical Engineering Laboratory, Process Engineering Department, Faculty of Technology, University of Saad Dahlab-Blida 1, Blida, Algeria;2. Clinical Department, Faculty of Medicine, University of Algiers 1, Algiers, Algeria |
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| Abstract: | The aim of this work was to stabilize oil-in-water nanoemulsion containing sage (salvia officinalis) essential oil, for enhancing its physicochemical stability and enlarging its industrial applications. New β-cyclodextrin nanosponges were synthesized by polycondensation using naphthalene dicarboxylic acid as cross-linking agent, the latter system was characterized by FTIR spectroscopy, SEM, BET, and powder XRD. Nanoemulsions stabilized by free β-cyclodextrin or nanosponges were prepared, their physicochemical properties were determined (particles size, zeta potential, viscosity, turbidity, and essential oil content) and their stability was studied at different storage temperatures (4?°C, 20?°C, and 40?°C) during 3?months. Pharmaceutical application of prepared nanoemulsions was investigated in vitro by dissolution test study and in vivo by their antidiabetic activity evaluation in rats. Sage essential oil nanoemulsion stabilized by β-cyclodextrin-naphthalene dicarboxylic acid nanosponges presents very high stability and promising uses in pharmaceutical industry. |
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| Keywords: | Nanodispersion salvia officinalis essential oil β-cyclodextrin nanosponge bioactivity enhancement physicochemical stability |
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