Recent Progress in Near Infrared Light Triggered Photodynamic Therapy |
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| Authors: | Kerong Deng Chunxia Li Shanshan Huang Bengang Xing Dayong Jin Qingguang Zeng Zhiyao Hou Jun Lin |
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| Affiliation: | 1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China;2. School of Applied Physics and Materials, Wuyi University, Jiangmen, Guangdong, China;3. College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, China;4. School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, Singapore;5. Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology, Sydney, NSW, Australia |
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| Abstract: | Nowadays, photodynamic therapy (PDT) is under the research spotlight as an appealing modality for various malignant tumors. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light‐triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for in vivo deep‐seated tumor. In this review, recent research progress related to the exploration of NIR light responsive PDT nanosystems is summarized. To address current obstacles of PDT treatment and facilitate the effective utilization, several innovative strategies are developed and introduced into PDT nanosystems, including the conjugation with targeted moieties, O2 self‐sufficient PDT, dual photosensitizers (PSs)‐loaded PDT nanoplatform, and PDT‐involved synergistic therapy. Finally, the potential challenges as well as the prospective for further development are also discussed. |
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| Keywords: | near infrared light photodynamic therapy photosensitizers targeted therapy tumor hypoxia |
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