Effects of material thickness and processing method on
poly(lactic-co-glycolic acid) degradation and mechanical
performance |
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Authors: | Reyhaneh Neghabat Shirazi Fawaz Aldabbagh William Ronan Andrea Erxleben Yury Rochev Peter McHugh |
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Affiliation: | 1.Biomechanics Research Centre (BMEC), Biomedical Engineering, College of Engineering and Informatics,National University of Ireland Galway,Galway,Ireland;2.School of Chemistry,National University of Ireland Galway,Galway,Ireland;3.Mechanical Engineering, College of Engineering and Informatics,National University of Ireland Galway,Galway,Ireland;4.National Centre for Biomedical Engineering Science (NCBES),National University of Ireland Galway,Galway,Ireland |
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Abstract: | In this study, the effects of material thickness and processing method on the degradation rate and the changes in the mechanical properties of poly(lactic-co-glycolic acid) material during simulated physiological degradation were investigated. Two types of poly(lactic-co-glycolic acid) materials were considered: 0.12?mm solvent-cast films and 1?mm compression-moulded plates. The experimental results presented in this study were compared to the experimental results of Shirazi et al. (Acta Biomaterialia 10(11):4695–703, 2014) for 0.25?mm solvent-cast films. These experimental observations were used to validate the computational modelling predictions of Shirazi et al. (J Mech Behav Biomed Mater 54: 48–59, 2016) on critical diffusion length scale and also to refine the model parameters. The specific material processing methods considered here did not have a significant effect on the degradation rate and the changes in mechanical properties during degradation; however, they influenced the initial molecular weight and they determined the stiffness and hardness of the poly(lactic-co-glycolic acid) material. The experimental observations strongly supported the computational modelling predictions that showed no significant difference in the degradation rate and the changes in the elastic modulus of poly(lactic-co-glycolic acid) films for thicknesses larger than 100?μm. |
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