Activatable Hybrid Nanotheranostics for Tetramodal Imaging and Synergistic Photothermal/Photodynamic Therapy |
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| Authors: | Shreya Goel Carolina A Ferreira Feng Chen Paul A Ellison Cerise M Siamof Todd E Barnhart Weibo Cai |
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| Affiliation: | 1. Department of Materials Science and Engineering, University of Wisconsin – Madison, WI, USA;2. Department of Biomedical Engineering, University of Wisconsin – Madison, WI, USA;3. Department of Radiology, University of Wisconsin – Madison, WI, USA;4. Department of Medical Physics, University of Wisconsin – Madison, WI, USA;5. University of Wisconsin Carbone Cancer Center, Madison, WI, USA |
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| Abstract: | A multifunctional core–satellite nanoconstruct is designed by assembling copper sulfide (CuS) nanoparticles on the surface of 89Zr]‐labeled hollow mesoporous silica nanoshells filled with porphyrin molecules, for effective cancer imaging and therapy. The hybrid nanotheranostic demonstrates three significant features: (1) simple and robust construction from biocompatible building blocks, demonstrating prolonged blood retention, enhanced tumor accumulation, and minimal long‐term systemic toxicity, (2) rationally selected functional moieties that interact together to enable simultaneous tetramodal (positron emission tomography/fluorescence/Cerenkov luminescence/Cerenkov radiation energy transfer) imaging for rapid and accurate delineation of tumors and multimodal image‐guided therapy in vivo, and (3) synergistic interaction between CuS‐mediated photothermal therapy and porphyrin‐mediated photodynamic therapy which results in complete tumor elimination within a day of treatment with no visible recurrence or side effects. Overall, this proof‐of‐concept study illustrates an efficient, generalized approach to design high‐performance core–satellite nanohybrids that can be easily tailored to combine a wide variety of imaging and therapeutic modalities for improved and personalized cancer theranostics in the future. |
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| Keywords: | cancer theranostics core– satellite nanoparticles multimodal imaging synergistic therapy |
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