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DNA计算中编码序列的优化设计方案*
引用本文:崔光照,张勋才,王延峰.DNA计算中编码序列的优化设计方案*[J].计算机应用研究,2007,24(7):195-198.
作者姓名:崔光照  张勋才  王延峰
作者单位:1. 郑州轻工业学院,电气信息工程学院,河南,郑州,450002
2. 郑州轻工业学院,电气信息工程学院,河南,郑州,450002;华中科技大学,控制科学与工程系,湖北,武汉,430074
基金项目:国家自然科学基金 , 河南省自然科学基金
摘    要:提出了一种优化设计方案.该方案的各项评价指标均优于根据以往文献提供的方法所能得到的最好结果.尤其是所提出的海明距离测度方法,进一步保证了特异性杂交产生的自由能远大于非特异性杂交所产生的自由能,便于进行DNA编码序列的设计与选择,为可控的DNA计算提供可靠有效的编码序列.

关 键 词:DNA计算  编码序列  热力学参数  物理特性  计算  编码序列  优化设计方案  DNA  Computing  Approach  Sequences  设计与选择  非特异性  自由能  杂交  测度方法  海明距离  结果  文献提供  评价指标
文章编号:1001-3695(2007)07-0195-04
修稿时间:2006-03-272006-07-04

Optimized Encoding Sequences Approach for DNA Computing
CUI Guang zhao,ZHANG Xun cai,WANG Yan feng.Optimized Encoding Sequences Approach for DNA Computing[J].Application Research of Computers,2007,24(7):195-198.
Authors:CUI Guang zhao  ZHANG Xun cai  WANG Yan feng
Abstract:Encoding sequences design is a crucial problem in DNA computing. Not only an optimized approach for constructing a set of encoding sequences was developed by using random generate and real-time filter algorithm, but several evaluation terms were proposed to compare with other existing sequence design systems. The comparison results show the performance of this approach outperforms the existing DNA sequence design systems, especially in preventing sequence serf-complementary from forming secondary structure and keeping the uniform melting temperature among sequences. It is convenient for user to design and select proper encoding sequences in silicon, and can provide reliable and effective encoding sequences for controllable DNA computing.
Keywords:DNA computing  encoding sequences  thermodynamic parameters  biophysics properties
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