Mapping and mining interictal pathological gamma (30-100 Hz) oscillations with clinical intracranial EEG in patients with epilepsy |
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Authors: | Otis Smart Douglas MausEric Marsh Dennis DlugosBrian Litt Kimford Meador |
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Affiliation: | a Intelligent Control Systems Laboratory, Georgia Institute of Technology, Atlanta, GA 30332, USA b Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA c Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA d Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA e Departments of Neurology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA f Department of Neurology, School of Medicine, Emory University, Atlanta, GA 30322, USA |
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Abstract: | Localizing an epileptic network is essential for guiding neurosurgery and antiepileptic medical devices as well as elucidating mechanisms that may explain seizure-generation and epilepsy. There is increasing evidence that pathological oscillations may be specific to diseased networks in patients with epilepsy and that these oscillations may be a key biomarker for generating and indentifying epileptic networks. We present a semi-automated method that detects, maps, and mines pathological gamma (30-100 Hz) oscillations (PGOs) in human epileptic brain to possibly localize epileptic networks. We apply the method to standard clinical iEEG (<100 Hz) with interictal PGOs and seizures from six patients with medically refractory epilepsy. We demonstrate that electrodes with consistent PGO discharges do not always coincide with clinically determined seizure onset zone (SOZ) electrodes but at times PGO-dense electrodes include secondary seizure-areas (SS) or even areas without seizures (NS). In 4/5 patients with epilepsy surgery, we observe poor (Engel Class 4) postsurgical outcomes and identify more PGO-activity in SS or NS than in SOZ. Additional studies are needed to further clarify the role of PGOs in epileptic brain. |
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Keywords: | Epileptic network Interictal epileptic discharge Pathological gamma oscillation Detection Mapping Data-mining |
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