L-苯丙氨酸苄酯盐酸盐的合成新工艺研究

提出了L-苯丙氨酸苄酯盐酸盐合成的新工艺路线，以L-苯丙氨酸为起始原料，先用二碳酸二叔丁酯保护氨基，再与氯化苄缩合得到N-叔丁氧羰基-L-苯丙氨酸苄酯，最后用氯化氢脱保护，得到L-苯丙氨酸苄酯盐酸盐. 通过实验探索了反应温度、原料配比、缚酸剂以及溶剂种类等工艺条件对合成的影响. 实验结果表明，在优化的工艺条件下，合成总收率为90.8%，为L-苯丙氨酸苄酯盐酸盐的合成提供了新选择.

Research on a New Techonology of Synthesis of L-Phenylalanine Benzyl Ester Hydrochloride

The paper proposes a new technology line to synthesize L-Phenylalanine benzyl ester hydrochloride. L-Phenylalanine benzyl ester hydrochloride is synthesized from L-phenylalalanine via tert-butoxycarbonylation of amino with di-tert-butyl dicarbonate，condensation with benzyl chloride，and deprotection with hydrochloride solution in ethyl acetate. Through the experiments，the effects of such technology conditions as reaction temperatures，ingredients ratios，acid-binding agents and solvents on the synthesis are explored. The experimental results show that under the optimized techonological conditions，the overall yield of target product is 90.8%，and thus a new option is provided for the synthesis of L-Phenylalanine Benzyl Ester Hydrochloride.