生物信息数据库分析 INHBA在结直肠癌中的表达及临床意义

抑制素βA作为转化生长因子-β（TGF-β）超家族成员，在不同肿瘤中具有促癌或抗癌作用。通过生物信息数据库分析了INHBA在结直肠癌中的表达水平及临床意义。结果显示INHBA在结直肠癌中明显高表达，且其高表达与结直肠癌的临床分期、T分期和N分期呈正相关。INHBA基因启动子的甲基化水平在结肠腺癌和直肠腺癌中都显著降低。生存分析显示，INHBA高表达的结直肠癌患者预后不良。此外，INHBA表达水平与肿瘤微环境中的绝大多数免疫细胞浸润水平呈正相关，尤其是巨噬细胞。同时，INHBA高表达与癌相关成纤维细胞(CAFs)和血管内皮细胞(VECs)高浸润水平也是密切相关。因此，INHBA在结直肠癌中高表达，参与结直肠癌的进展，有望成为预后和治疗的潜在标志物。

Expression and Clinical Significance of INHBA in Colorectal Cancer Based on Bioinformatics Databases

Inhibitors beta A (INHBA), as a member of transforming growth factor-β (TGF-β) superfamily, have pro-cancer or anti-cancer effects in different tumors. This study aims to investigate the expression and clinical significance of INHBA in colorectal cancer through bioinformatics databases. The results showed that INHBA expression was significantly upregulated in colorectal cancer, and its high expression was positively correlated with clinical stages, T stages and N stages of colorectal cancer. The methylation level of INHBA promoter was significantly reduced in both colon and rectal cancer. Survival analysis showed that colorectal cancer patients with high INHBA expression had poor prognosis. Moreover, INHBA expression was positively correlated with the infiltration levels of most immune cells in the tumor microenvironment, especially macrophages. INHBA high expression was also closely related to the high infiltration levels of cancer-associated fibroblasts (CAFs) and vascular endothelial cells (VECs). Taken together, INHBA is highly expressed in colorectal cancer tissues and involved in the development of colorectal cancer, which is expected to be a potential marker for prognosis and treatment.