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3-氧杂二环己烷类衍生物的合成方法研究
引用本文:茹婷婷,丁晓岩.3-氧杂二环己烷类衍生物的合成方法研究[J].吉林建筑工程学院学报,2013(5):69-71.
作者姓名:茹婷婷  丁晓岩
作者单位:[1]吉林建筑大学基础科学部,长春130118 [2]通化市东昌区江东乡中心小学,通化134000
摘    要:3-氧杂二环己烷类衍生物在具有生物活性的天然产物中经常作为基本分子结构单元出现,在一些具有药物活性的化合物中也存在该结构单元.本文选用廉价的乙烯基环丙烷类化合物为反应原料,使其和N-溴代丁二酰亚胺发生化学反应,制备出具有生物活性的化合物.该反应条件经过优化、选择,发现可以通过一锅两步法制备3-氧二环己烷类化合物.

关 键 词:三元环并五元环  3-氧杂二环己烷  有机合成

A Method for Synthesis of 3-oxa-bicyclo Hexane Derivatives
RU Ting-ting,DING Xiao-yan.A Method for Synthesis of 3-oxa-bicyclo Hexane Derivatives[J].Journal of Jilin Architectural and Civil Engineering,2013(5):69-71.
Authors:RU Ting-ting  DING Xiao-yan
Affiliation:1: Department of Basic Sciences, Jilin Jianzhu University, Changchun, China 130118; 2: Dongchang District Jiangdong Central Primary School, Tonghua, China 134000)
Abstract:3 - oxa - bicyclo hexane compounds have inportant biological activity of the basic structural units of natu- ral products, but also a number of improtant basic framework of pharmaceutical active compounds. This paper from the molecular design proceeding from the easily avalible vinyl cyclopropane compounds and small organic molecules NBS, through the choic of reaction conditions to optimize the new strategy of synthetic 3 - oxa - bicyclo hexane derivatives.
Keywords:cyclopropane and five - memberred ring  3 - oxa - bicyclo hexane  organic synthesis
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