Raney Ni催化合成3-甲基吲哚的方法研究

吲哚是一种重要的精细化工原料,广泛应用于医药、农药、香料、染料、食品和饲料添加剂等领域.其传统的制备方法是采用煤焦油分馏法,但由于资源有限,而且分离装置繁杂,能耗大,因而化学合成技术应运而生.本文介绍了一种以邻硝基乙苯为原料生成邻硝基苯乙醇,再经过还原,环合反应过程,最终得到产物3-甲基吲哚.此合成方法具有操作简单、产量高、能耗低和污染小等优点.

A Method for Synthesis of 3-methyl Indole by Raney Ni Catayst

Indole is an important fine chemical widely used for the syntheses of pharmaceuticals, agricultural chemi- cals, perfumes, dyes, and additives to foods and feed stocks. 3 - methyl indole is a important intermediate to a num- ber of useful indole derivatives. Therefore, facile and economical synthese of this article is intensively pursued by re- search workers in the field. This paper using o - nitro ethyl benzene as raw material, hydroxymethylation with formal- dehyde under alkaline conditions gave o -nitro phenyl ethanol. In this study we chose to develop a Raney Ni cata- lyst used both for reduction of the nitro group as well as for the indole production in the last step.