荩草的化学成分

荩草资源丰富且有悠久的民间用药历史，为了寻找其活性成分，丰富荩草中化合物的类型，对荩草地上部分的化学成分进行系统的研究．用80％乙醇提取荩草地上部分，所得浸膏加水稀释后，依次用石油醚，氯仿，乙酸乙酯和正丁醇萃取，对氯仿和乙酸乙酯部分浸膏采用各种硅胶柱色谱和重结晶方法进行分离纯化，利用熔点，溶解性，颜色反应等理化性质和紫外光谱、红外光谱、质谱以及氢（1）与碳（13）核磁共振以及二维核磁共振技术无畸变极化转移增强-135，杂核多键相关和杂核单键相关等波谱数据确定了分离所得物质的结构．从荩草中分离并鉴定了10个化合物，分别为：3，5，7-三羟基-3’，5＇-二甲氧基黄酮（1）、去氢紫堇碱（2）、△5，22豆甾醇-3-O-β—D-葡萄糖苷（3）、正十四烷（4）、正十五烷（5）、正十八烷（6）、正十九烷（7）、正二十二烷（8）、正二十四烷（9）、二十五烷（10）．这10个化合物中化合物1～3为首次从该植物中分离得到．

Chemical constituents of Arthraxon hispidus(Thunb) Makino

Arthraxon hispidus is rich in resources and has a long medication history. In order to find the active ingredient and enrich the types of compounds, the system study on its chemical constituents was carried out. The chemical constituents of A. hispidus were extracted by 80% ethanol. The residue was suspended in water and then extracted successively with Petroleum ether, chloroform, ethyl acetate and n-butanol. Chloroform part and ethyl acetate part were isolated and purified by silica gel column chromatography and recrystallization. Their structures were characterized by chromogenie reaction, ultravioet, infrared, mass spectrometry, 1H and 13 C nuclear magnetic resonance and 2 D nuclear magnetic resonance experiments such as Distortionless Enhanced by Polarization Transfer, Heteronuelear Muliple Boan Correlation and Heteronuclear Single Boan Correlation. Ten compounds including 3,5,7-trihydroxy-3 r, 5＇-dimethoxylflavone （1）, dehydrocorydaline （2）, Stigmasterol-3-O-β-D- glucoside （3）, n-Tetradeeane （4）, n-Pentadecane （5）, n-Oetadecane （6）, n-Nonadeeane （7）, n- Docosane （8）, n-Tetracosane （9）, n-Pentacosane （10） were isolated and identified. Among these ten compounds, compounds 1 -3 are obtained from this plant for the first time.