Development and characterization of a poly (vinyl alcohol) and sodium alginate blend foam for wound dressing loaded with propolis and all-trans retinoic acid |
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Authors: | Pedro Henrique Souza Cesar Caio Vinicius Lima Natarelli Juliano Elvis de Oliveira Paula Ariane Andrade Tamara Leite dos Santos Silvana Marcussi |
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Affiliation: | 1. Department of Chemistry, Biochemistry Laboratory, Universidade Federal de Lavras (UFLA), Lavras, Brazil;2. Department of Materials Science and Engineering, Universidade Federal de São Carlos (UFSCar), São Paulo, Brazil;3. Department of Engineering, Laboratory of Materials and Biosystems (LAMAB), Universidade Federal de Lavras (UFLA), Lavras, Brazil;4. Phytopathology department, Laboratory of electron microscopy and ultrastructural analysis, Universidade Federal de Lavras (UFLA), Lavras, Brazil |
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Abstract: | Propolis is a complex mixture of phytochemicals, with antibacterial, anti-inflammatory, and healing properties. All-trans retinoic acid is implicated in wound healing by stimulating angiogenesis, cell recruitment, extracellular matrix deposition, and reepithelization. The incorporation of both agents to a polymeric wound dressing composed of poly (vinyl alcohol) and sodium alginate may result in improved healing allied to controlled release, fluid uptake, and wound protection. In the present work, we have physically characterized this wound dressing and analyzed its release kinetics. The anti-inflammatory capacity was assayed. SEM images showed a highly porous structure with a diverse morphology. FTIR spectra displayed a highly cross-linked structure with both polymers connected by hydrogen bonds and acetal bridges. The wound dressings were able to retain great volumes of PBS. Propolis and vitamin A releasing behavior were maintained for 6 h. The concentrations of the biologically active substances were capable of promoting anti-inflammatory action in an erythrocyte membrane stabilization model. The wound dressings obtained here showed adequate physical properties. The fabrication process did not affect the anti-inflammatory capacity. Further tests are needed to ensure the biocompatibility and to assess other biological activities of the therapeutic agents. |
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Keywords: | biomaterials biomedical applications biopolymers and renewable polymers |
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