| 利用乳液酶膜反应器拆分萘普生甲酯实验研究 |
| |
| 引用本文： | 尚雁,李娜,傅博诣,黄卓楠,傅强,方琪.利用乳液酶膜反应器拆分萘普生甲酯实验研究[J].化学工程,2010,38(4). |
| |
| 作者姓名： | 尚雁 李娜 傅博诣 黄卓楠 傅强 方琪 |
| |
| 作者单位： | 1. 西安交通大学能动学院,陕西西安,710049
2. 西安交通大学医学院,陕西西安,710061 |
| |
| 基金项目： | 国家自然科学基金资助项目(20406014);;国家重点基础研究计划(“973”项目)资助项目(2009CB2199006) |
| |
| 摘 要： | 利用乳液酶膜反应器进行外消旋萘普生甲酯的水解反应,以制备光学纯对映体(S)-萘普生,反应同时从膜透过侧收集产物,实现反应分离一体化。实验研究了固定酶前后膜传质阻力和反应过程的水相跨膜通量,考察了透过侧的产物浓度、反应器的转化率、产量和对映体选择性。结果表明:固定化酶引起的传质阻力远大于膜本身的阻力;透过侧的产物浓度与水相渗透通量密切相关,通量较低时,产物浓度较高;固定化酶的初始反应速率为3.660μmol/(h.g),为自由酶的20倍以上,固定化酶的对映体过剩值为99%—100%,远高于自由酶的选择性,表明该反应体系为脂肪酶催化拆分反应提供了良好环境。
|
| 关 键 词： | 固定化脂肪酶 乳液酶膜反应器 预混合式膜乳化法 手性拆分 (S)-萘普生 |
Experimental study on resolution of naproxen methyl esters in an emulsion enzyme membrane reactor |
| |
| SHANG Yan,LI Na,FU Bo-yi,HUANG Zhuo-nan,FU Qiang,FANG Qi.Experimental study on resolution of naproxen methyl esters in an emulsion enzyme membrane reactor[J].Chemical Engineering,2010,38(4). |
| |
| Authors: | SHANG Yan LI Na FU Bo-yi HUANG Zhuo-nan FU Qiang FANG Qi |
| |
| Affiliation: | SHANG Yan1,LI Na1,FU Bo-yi1,HUANG Zhuo-nan1,FU Qiang2,FANG Qi2 |
| |
| Abstract: | The hydrolysis reaction of racemic naproxen methyl esters was carried out in emulsion enzyme membrane reactor to produce optical pure(S)-naproxen.The product was simultaneously separated and collected from the permeate side of the membrane during the reaction process,thus realizing the combination of reaction and separation in the system.The mass transfer resistance of membrane before and after the immobilization of enzyme as well as the permeation rate of aqueous phase through the membrane were studied exp... |
| |
| Keywords: | immobilized lipase emulsion enzyme membrane reactor premix membrane emulsification chiral resolution (S) -naproxen |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
