十二水合硫酸铁铵催化合成氯乙酸异戊酯的研究

以十二水合硫酸铁铵为催化剂、正己烷为带水剂，以氟乙酸与异戊醇为原料合成氯乙酸异戊酯。考察了醇酸摩尔比、催化荆用量、带水剂用量、反应时间、不同的带水剂及催化剂的重复使用对酯收率的影响。结果表明，在氯乙酸用量为0．1mol、醇酸摩尔比为1．2：l、催化剂十二水合硫酸铁铵用量为1．5g、带水剂正己烷用量为15mL、反应时问为1．5h、反应温度为78-98℃的优化合成条件下，氯乙酸异戊酯收率达到89．6％。

Synthesis of Isoamyl Chloroacetate Catalyzed by Ammonium Ferric Sulfate Hydrate

Synthesis of isoamyl chloroacetate using ammonium ferric sulfate hydrate as catalyst is studied. The influential factors of synthetic reaction are investigated and the optimal conditions studied. Under the opti- mum conditions as follows, chloroacetic acid amount is 0. 1 mol, the molar ratio of isoamyl alcohol to chloroace- tic acid is 1.2 ： 1 ,the catalyst dosage is 1.5 g,the n-hexane amount is 15 mL,the reaction time is 1.5 h,and the reaction temperature is 78-98 ℃ ,the yield of isoamyl chloroacetatc reachs 89.6%.