| 手性合成（R）-2-羟基苯丁酸乙酯的研究 |
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| 引用本文： | 刘昱,李翔,刘小成,何嘉俊,刘端.手性合成（R）-2-羟基苯丁酸乙酯的研究[J].化学与生物工程,2009,26(7):37-39. |
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| 作者姓名： | 刘昱 李翔 刘小成 何嘉俊 刘端 |
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| 作者单位： | 湖北省化学研究院,湖北,武汉,430074 |
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| 摘 要： | (R)-2-羟基苯丁酸乙酯是合成普利类抗高血压药物的重要手性中间体.通过正交实验优化了(R)-2-羟基苯丁酸乙酯中间体2-氧代苯丁酸乙酯的合成,利用亚硫酸氢钠提纯,得到了纯度为98%的2-氧代苯丁酸乙酯;添加8-羟基喹啉来提高不对称氢化的选择性,可以提高产品e.e.值.
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| 关 键 词： | (R)-2-羟基苯丁酸乙酯 2-氧代苯丁酸乙酯 不对称氢化 提纯 |
Study on the Enantioselective Synthesis of Ethyl(R)-2-hydroxy-4-phenylbutanate |
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| LIU Yu,LI Xiang,LIU Xiao-cheng,HE Jia-jun,LIU Duan.Study on the Enantioselective Synthesis of Ethyl(R)-2-hydroxy-4-phenylbutanate[J].Chemistry & Bioengineering,2009,26(7):37-39. |
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| Authors: | LIU Yu LI Xiang LIU Xiao-cheng HE Jia-jun LIU Duan |
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| Affiliation: | Hubei Institute of Chemistry;Wuhan 430074;China |
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| Abstract: | Ethyl(R)-2-hydroxy-4-phenylbutanate is an important chiral intermediate for ACEI drugs.In this paper,orthogonal experiment was applied to optimize the synthesis of intermediate ethyl 2-oxo-4-phenylbutanate,and sodium bisulfite was used to obtain the intermediate with purity of 98%.8-Hydroxyquinoline was added to improve the selectivity of asymmetric hydrogenation and it was found that the e.e.value of the product was enhanced. |
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| Keywords: | ethyl(R)-2-hydroxy-4-phenylbutanate ethyl 2-oxo-4-phenylbutanate asymmetric hydrogenation purification |
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