| 阿达帕林的合成工艺研究 |
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| 引用本文： | 李现城,王宏雁,孙冲.阿达帕林的合成工艺研究[J].河南化工,2011(15):37-40. |
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| 作者姓名： | 李现城 王宏雁 孙冲 |
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| 作者单位： | 1. 河南省地质勘探局第一地质工程院,河南驻马店,463000
2. 河南工业大学化学化工学院,河南郑州,450001 |
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| 摘 要： | 以1-金刚烷醇、4～溴苯酚为原料，在浓硫酸催化下制得2-（1-金刚烷基）-4-溴苯酚，产物再用硫酸二甲酯甲基化得到2-（1-金刚烷基）-4-溴苯甲醚，2-（1-金刚烷基）～4-溴苯甲醚的格氏化产物再与6-溴-2-萘甲酸甲酯反应，制得6～3-（1-金刚烷基）-4-甲氧基苯基]-2-萘甲酸甲酯，该产品在氢氧化钠作用下皂化...
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| 关 键 词： | 阿达帕林 合成 工艺 |
Study on Synthetic Process of Adapalene |
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| LI Xian-cheng,WANG Hong-yan,SUN Chong.Study on Synthetic Process of Adapalene[J].Henan Chemical Industry,2011(15):37-40. |
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| Authors: | LI Xian-cheng WANG Hong-yan SUN Chong |
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| Affiliation: | LI Xian-cheng1,WANG Hong-yan2,SUN Chong2(1.Instututue of Geological Engineering of Usgs of Henan,Zhumadian 463000,China,2.College of Chemical Engineering,Henna University of Technology,Zhengzhou 450001,China) |
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| Abstract: | Adapalene is synthesized from 4-bromophenol and 1-adamantanol by a four-step reaction,First,4-bromophenol is alkylated by 1-adamantanol from 2-(1-adamantyl)-4-bromophnol,the compound 2-(1-adamantyl)-4-bromophenol is reacted with dimethylsulfate to give 2-(1-adamantyl)-4-bromoanisole,compound 2-(1-adamantyl)-4-bromoanisole is condensed to 6-bromo-2-naphthoic acid methyl ester to produce 6-3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate.Last,saponification of compound 6-3-(1-adamantyl)-4-methoxyphenyl]-2-naph... |
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| Keywords: | adapalene synthesis process |
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