| 反相高效液相色谱法测定化妆品中羟基喹啉 |
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| 引用本文： | 张鹏祥,刘洋,高晓譞,徐梦晴,张严赛,赵华.反相高效液相色谱法测定化妆品中羟基喹啉[J].日用化学工业,2011,41(6):462-464. |
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| 作者姓名： | 张鹏祥 刘洋 高晓譞 徐梦晴 张严赛 赵华 |
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| 作者单位： | 1. 北京工商大学理学院,北京,100048
2. 中国香料香精化妆品工业协会,北京,100079 |
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| 基金项目： | 国家食品药品监督管理局专项资助项目[2010] |
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| 摘 要： | 采用反相高效液相色谱法测定化妆品中羟基喹啉的含量.色谱条件为:Kromasil C18色谱柱(250 mm×4.6 mm i.d.,5μm),流动相为V(甲醇):V(0.01 mol/L癸烷磺酸钠溶液(磷酸调pH=2.25))=62:38的混合溶液,流速1.0 mL/min,检测波长240 nm,柱温25℃,进样量20μL.结果表明,该方法的检出限为2.254 μg/g,线性范围为1.0～100.0μg/mL,回收率为95.5％～100.1％,RSD为0.07％～2.18％.
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| 关 键 词： | 化妆品 羟基喹啉 反相高效液相色谱法 测定 |
Determination of hydroxyquinoline in cosmetics by reversed-phase high performance liquid chromatography |
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| ZHANG Peng-xiang
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LIU Yang
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GAO Xiao-xuan
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XU Meng-qing
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ZHANG Yan-sai
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ZHAO Hua.Determination of hydroxyquinoline in cosmetics by reversed-phase high performance liquid chromatography[J].China Surfactant Detergent & Cosmetics,2011,41(6):462-464. |
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| Authors: | ZHANG Peng-xiang LIU Yang GAO Xiao-xuan XU Meng-qing ZHANG Yan-sai ZHAO Hua |
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| Affiliation: | 1(1.School of Science,Beijing Technology and Business University,Beijing 100048,China; 2.China Association of Fragrance Flavor and Cosmetic Industries,Beijing 100079,China) |
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| Abstract: | A reversed-phase high performance liquid chromatographic method was developed for the determination of hydroxyquinoline in cosmetics.The determination process was carried out on a Kromasil C18 column,using a mixture composed of methanol and 0.01 mol/L aqueous solution of sodium decyl sulfonate with pH adjusted to 2.25 by phosphoric acid at a volume ratio of 62:38 as mobile phase for isocratic elution.The flow rate was 1.0 mL/min and the column temperature was 25 ℃.Detection was carried out at 240 nm.The limit of detection is 2.254 μg/g.The linear plot ranges between 1.0 and 100.0 μg/mL.Average spiked recoveries are 95.5%～100.1% with the relative standard deviations of 0.07%～2.18%. |
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| Keywords: | cosmetics hydroxyquinoline reversed-phase high performance liquid chromatography determination |
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