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A boronic acid-based fluorescent hydrogel for monosaccharide detection
Authors:Suying Xu  Adam C Sedgwick  Souad A Elfeky  Wenbo Chen  Ashley S Jones  George T Williams  A Toby A Jenkins  Steven D Bull  John S Fossey  Tony D James
Abstract:A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection. In solution, the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose, and an expected trend in apparent binding constants, as judged by a fluorescence response where D-fructose>D-galactose>D-mannose>D-glucose. The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of D-fructose resulting in a 10-fold enhancement (≤0.25 mol/L).
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