| 光气法合成邻羟基苯甲腈研究 |
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| 引用本文： | 何伟明,郭嘉昒,周艳明.光气法合成邻羟基苯甲腈研究[J].上海化工,2012,37(6):10-12. |
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| 作者姓名： | 何伟明 郭嘉昒 周艳明 |
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| 作者单位： | 1. 四川科技职工大学,四川成都,610101
2. 山西应用化学研究所,山西太原,003207 |
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| 基金项目： | 四川科技职工大学科技研发计划项目 |
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| 摘 要： | 邻羟基苯甲腈是一种重要的化工中间体,广泛应用于医药、农药、染料、高分子合成等工业生产中。研究了水杨酰胺和光气在甲苯溶液中合成邻羟基苯甲腈的反应,得出最佳反应条件为n(水杨酰胺)∶n(光气)=1∶1.2、反应温度90～100℃、反应时间5 h。经溶剂甲苯回收后,将邻羟基苯甲腈重结晶提纯,产品质量分数为95.1%,收率达92.3%。
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| 关 键 词： | 邻羟基苯甲腈 水杨酰胺 光气 合成 |
Study on Synthesis of 2-hydroxybenzonitrile by Phosgenation |
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| He Weiming Guo Jiahu Zhou yanming.Study on Synthesis of 2-hydroxybenzonitrile by Phosgenation[J].Shanghai Chemical Industry,2012,37(6):10-12. |
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| Authors: | He Weiming Guo Jiahu Zhou yanming |
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| Affiliation: | He Weiming Guo Jiahu Zhou yanming |
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| Abstract: | 2-hydroxyhenzonitrile is a significant chemical intermediate, which is widely applied in the production of pharmaceutical, agrochemical, dyestuffs and polymer synthesis industry. In this paper, preparation of 2-hydroxybenzonitrile by the reaction of salicylamide and carbonyl chloride in toluene was studied. The optimum process conditions were determined： n（salicylamide）：n（earbonyl chloride）=1.0：1.2, reaction temperature 90-100 ℃ and reaction time 5 h. 2-hydroxybenzonitrile was purified by recrystallization after it had been recovered in toluene. The assay of 2-hydroxybenzonitrile was 95.1%, and the yield was 92.3%. |
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| Keywords: | 2-hydroxyhenzonitrile Salicylamide Carbonyl chloride Synthesis |
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