| N,N-二乙基氨基乙基-3,4-二氯苄基醚及其类似物的合成 |
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| 引用本文： | 宋瑞峰.N,N-二乙基氨基乙基-3,4-二氯苄基醚及其类似物的合成[J].精细化工,2008,25(7). |
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| 作者姓名： | 宋瑞峰 |
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| 作者单位： | 苏州科技学院,化学与生物工程学院,江苏,苏州,215009 |
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| 基金项目： | 江苏省高校青蓝工程基金 |
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| 摘 要： | 用相转移催化法合成了5个N,N-二乙基氨基乙基-3,4-二氯苄基醚及其类似物,产率为72%~86%。适宜的反应条件是:以二烷基氨基乙醇、3,4-二氯氯化苄为原料,在固体氢氧化钠作用下,四丁基溴化铵为相转移催化剂,甲苯为溶剂,n(R1R2NCH2CH2OH)∶n(C l2ArCH2C l)∶n(NaOH)∶n(PTC)=1.1∶1∶2∶0.05,反应时间2 h,温度70℃。产物经沸点、元素分析、红外光谱、核磁共振氢谱予以确证。
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| 关 键 词： | N N-二烷基氨基乙基-3 4-二氯苄基醚 相转移催化 3 4-二氯氯化苄 |
Syntheses of N,N-Diethylaminoethyl 3,4-Dichlorobenzyl Ether and Its Analogues |
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| SONG Rui-feng.Syntheses of N,N-Diethylaminoethyl 3,4-Dichlorobenzyl Ether and Its Analogues[J].Fine Chemicals,2008,25(7). |
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| Authors: | SONG Rui-feng |
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| Abstract: | Five bioregulator compounds N,N-diethylaminoethyl 3,4-dichlorobenzyl ether and its analogues were synthesized in good yields(72%～86%)from the reaction of dialkylaminoethanol with 3,4-dichlorobenzyl chloride by using Bu4NBr as phase-transfer catalyst,toluene as solvent,adding sodium hydroxide solid,in molar ratio n(R1R2NCH2CH2OH)∶n(Cl2ArCH2Cl)∶n(NaOH)∶n(PTC)=1.1∶1∶2∶0.05,for 2 h at 70 ℃.Structures of the products were confirmed by b.p determination,elementary analysis,IR and 1HNMR spectrometry. |
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| Keywords: | N N-dialkylaminoethyl 3 4-dichlorobenzyl ether phase-transfer catalysis 3 4-dichlorobenzyl chloride |
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