微反应技术在氟化反应中的应用

有机含氟化合物因其独特的理化性质被广泛应用于精细化工领域,但传统釜式氟化仍存在在线量大、易产生热点等问题,而微反应技术作为一种高效传质传热的新型技术,有望解决以上问题。因此,该文根据底物类型,综述了近二十年微反应技术的研究进展,以及微反应技术在氟化反应中的应用。微反应技术的应用可以极大地提高氟化效率,相信微反应技术的出现将推动氟化反应向着更为高效、安全、环保、可控及连续化的方向发展,但仍需突破釜式思考模式,并对微反应技术的连续后处理过程进行进一步研究。

The Application of Microreaction Technology in Fluorination

The organic fluorochemical has an extensive application in the field of fine chemicals due to the unique physical properties. However, there are some problems existed in the traditional fluorination process. There is no doubt that, as a new technology of high efficiency mass and heat transfer, microreaction technology is expected to solve some of the problems. Therefore, according to the types of fluorinated substrate, the main progress made in the field of microreaction technology in recent twenty years, and the application of microreaction technology in fluorination is reviewed. The application of microreaction technology can greatly improve the of efficiency fluorination and it is believed that the emergence of microreaction technology will promote the development of fluorination reaction towards a more efficient, safe, environmentally friendly, controllable and continuous direction. Neverthless, it is necessary to break through the traditional thinking mode and further study on the application of microreaction technology in continuous post-processing.