Dietary conjugated linoleic acid did not alter immune status in young healthy women |
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Authors: | D S Kelley P C Taylor I L Rudolph P Benito G J Nelson B E Mackey K L Erickson |
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Affiliation: | (1) Western Human Nutrition Research Center, University of California, Department of Nutrition, U.S. Department of Agriculture, Agricultural Research Service, One Shields Ave., 95616 Davis, California;(2) Western Regional Research Center, Albany, California;(3) Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California |
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Abstract: | The purpose of this study was to examine whether conjugated linoleic acid (CLA) supplementation in human diets would enhance
indices of immune status as reported by others for animal models. Seventeen women, 20–41 yr, participated in a 93-d study
conducted in two cohorts of 9 and 8 women at the Metabolic Research Unit of Western Human Nutrition Research Center. Seven
subjects were fed the basal diet (19, 30 and 51% energy from protein, fat, and carbohydrate, respectively) throughout the
study. The remaining 10 subjects were fed the basal diet for the first 30 d, followed by 3.9 g CLA (Tonalin)/d for the next
63 d. CLA made up 65% of the fatty acids in the Tonalin capsules, with the following isomeric composition: t10, c12, 22.6%; c11, t13, 23.6%; c9, t11, 17.6%; t8, c10, 16.6%; and other isomers 19.6%. Most indices of immune response were tested at weekly intervals, three times at the end
of each period (stabilization/intervention); delayed-type hypersensitivity (DTH) to a panel of six recall antigens was tested
on study day 30 and 90; all subjects were immunized on study day 65 with an influenza vaccine, and antibody titers were examined
in the sera collected on day 65 and 92. None of the indices of immune status tested (number of circulating white blood cells,
granulocytes, monocytes, lymphocytes, and their subsets, lymphocytes proliferation in response to phytohemagglutinin, and
influenza vaccine, serum influenza antibody titers, and DTH response) were altered during the study in either dietary group.
Thus, in contrast to the reports with animal models, CLA feeding to young healthy women did not alter any of the indices of
immune status tested. These data suggest that short-term CLA supplementation in healthy volunteers is safe, but it does not
have any added benefit to their immune status.
Parts of data included here were published as an abstract for the Experimental Biology 2000, meeting. |
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