| 6-苯甲酰基-2,2-二甲基-7-羟基色满的合成研究 |
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| 引用本文： | 付娟,徐慧兰,左莉,胡春.6-苯甲酰基-2,2-二甲基-7-羟基色满的合成研究[J].精细化工中间体,2011,41(4):34-36. |
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| 作者姓名： | 付娟 徐慧兰 左莉 胡春 |
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| 作者单位： | 沈阳药科大学制药工程学院,辽宁沈阳,110016 |
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| 基金项目： | 国家自然科学基金资助项目(20474053) |
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| 摘 要： | 以间苯二酚、3-甲基-2-丁烯酸为原料经过环合反应,锌汞齐还原,与酰氯反应成酯,Fries重排得到6-苯甲酰基-2,2-二甲基-7-羟基色满,总收率49.6%。该路线原料廉价易得、操作简单、副反应少、收率较高,具有工业化应用前景。
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| 关 键 词： | 6-苯甲酰基-2 2-二甲基-7-羟基色满 间苯二酚 3-甲基-2-丁烯酸 合成 |
Synthesis of 6-Benzoyl-2,2-dimethyl-7-hydroxychroman |
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| FU Juan,XU Hui-lan,ZUO Li,HU Chun.Synthesis of 6-Benzoyl-2,2-dimethyl-7-hydroxychroman[J].Fine Chemical Intermediates,2011,41(4):34-36. |
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| Authors: | FU Juan XU Hui-lan ZUO Li HU Chun |
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| Affiliation: | FU Juan,XU Hui-lan,ZUO Li,HU Chun*(School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | 6-Benzoyl-2,2-dimethyl-7-hydroxychroman was synthesized from resorcinol and 3-methylbut-2-enoic acid in the overall yield of 49.6% via cyclization,Clemmensen reduction,and Fries' rearrangement.This synthetic procedure is suitable for industrial preparation with cheap raw material,convenient operation,low side reactions and high yield. |
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| Keywords: | 6-benzoyl-2 2-dimethyl-7-hydroxychroman resorcinol 3-methylbut-2-enoic acid synthesis |
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