| 2-氨基-5-溴烟醛的合成 |
| |
| 引用本文： | 徐珊,朱五福,郑鹏武,吴英良.2-氨基-5-溴烟醛的合成[J].精细化工中间体,2013,43(3):26-28. |
| |
| 作者姓名： | 徐珊 朱五福 郑鹏武 吴英良 |
| |
| 作者单位： | 1. 沈阳药科大学生命科学与生物制药学院,辽宁沈阳,110016
2. 江西科技师范大学药学院,江西南昌,330013 |
| |
| 基金项目： | 江西省教育厅科技计划项目 |
| |
| 摘 要： | 以烟酰胺为原料,经环合、酸解、溴代反应制得2-氨基-5-溴烟醛(1),并对其制备工艺进行优化和改进,结构经ESI-MS、1H NMR确证。改进后的工艺合成路线较短,操作简单,反应条件较温和,生产成本低,收率为37.4%(以烟酰胺计),具有较好的工业应用前景。
|
| 关 键 词： | 烟酰胺 2-氨基-5-溴烟醛 合成 |
Synthesis of 2-Amino-5-bromonicotinaldehyde |
| |
| XU Shan,ZHU Wu-fu,ZHENG Peng-wu,WU Ying-liang.Synthesis of 2-Amino-5-bromonicotinaldehyde[J].Fine Chemical Intermediates,2013,43(3):26-28. |
| |
| Authors: | XU Shan ZHU Wu-fu ZHENG Peng-wu WU Ying-liang |
| |
| Affiliation: | 1(1.School of Life Science and Biopharmaceuticals,Shenyang Pharmaceutical University,Shenyang 110016,China;2.School of Pharmacy,Jiangxi Science and Technology Normal University,Nanchang 330013,China) |
| |
| Abstract: | 2-Amino-5-bromonicotinaldehyde was prepared from nicotinamide in an overall yield of 37.4% via cyclization,acidolysis and bromination,and its structure was confirmed by 1H NMR and ESI-MS.The improved process has the advantage of less steps,simple operation,low cost,short reaction time and it is also suitable for industrial production. |
| |
| Keywords: | nicotinamide 2-amino-5-bromonicotinaldehyde synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
