| 4-氨基-3,5-二甲基吡唑合成工艺改进 |
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| 引用本文： | 罗义芬,葛忠学,王伯周,贾思媛,王锡杰.4-氨基-3,5-二甲基吡唑合成工艺改进[J].精细化工中间体,2007,37(3):47-48,57. |
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| 作者姓名： | 罗义芬 葛忠学 王伯周 贾思媛 王锡杰 |
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| 作者单位： | 西安近代化学研究所,陕西,西安,710065 |
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| 摘 要： | 以乙酰丙酮为起始原料,采用两步法新工艺合成了目标产物4-氨基-3,5-二甲基吡唑,总收率达到71.7%;对肟化反应条件进行了优化,确定适宜的反应条件为:n(乙酰丙酮)∶n(亚硝酸钠)=1∶1,反应温度5～10℃,反应时间20min。
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| 关 键 词： | 4-氨基-3 5-二甲基吡唑 3-肟基戊二酮 合成 |
| 文章编号： | 1009-9212（2007）03-0047-02 |
| 修稿时间： | 2007-02-08 |
An Improvement on Synthesis of 4-Amino-3,5-dimethylpyrazole |
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| LUO Yi-fen,GE Zhong-xue,WANG Bo-zhou,JIA Si-yuan,WANG Xi-jie.An Improvement on Synthesis of 4-Amino-3,5-dimethylpyrazole[J].Fine Chemical Intermediates,2007,37(3):47-48,57. |
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| Authors: | LUO Yi-fen GE Zhong-xue WANG Bo-zhou JIA Si-yuan WANG Xi-jie |
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| Abstract: | 4-Amino-3,5-dimethylpyrazole was synthesized from aletylacetone via two reactions. The overall yield was up to 71.7%. Furthermore,the oximation conditions were optimized,and the optimum conditions were as follows,the mole ratio of sodium nitrite to acetylacetone is 1 ∶ 1,the reaction temperature varies from 5 to 10℃ and the reaction time is 20 min. |
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| Keywords: | 4-amino-3 5-dimethylpyrazole acetylacetone-3-oxime synthesis |
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