| 微波合成2-羟基-4-甲氧基二苯甲酮 |
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| 引用本文： | 王德传,余德超,周小圆.微波合成2-羟基-4-甲氧基二苯甲酮[J].精细化工中间体,2010,40(6). |
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| 作者姓名： | 王德传 余德超 周小圆 |
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| 作者单位： | 中国药科大学,有机化学教研室,江苏,南京,211198 |
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| 摘 要： | 以2,4-二羟基二苯甲酮(UV-0)及碳酸二甲酯(DMC)为原料,微波合成2-羟基-4-甲氧基二苯甲酮(UV-9)。利用正交实验设计法对影响收率诸因素进行了考察,通过红外、核磁共振氢谱和质谱对产物结构进行表征。运用社会科学统计软件包(SPSS)进行实验数据处理,确定优化工艺条件,与常规加热反应相比,采用微波法缩短了反应时间,产物收率达到了74.38%。
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| 关 键 词： | 微波合成 2 4-二羟基二苯甲酮 碳酸二甲酯 2-羟基-4-甲氧基二苯甲酮 |
Synthesis of 2-Hydroxy-4-methoxybenzophenone under Microwave |
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| WANG De-chuan,YU De-chao,ZHOU Xiao-yuan.Synthesis of 2-Hydroxy-4-methoxybenzophenone under Microwave[J].Fine Chemical Intermediates,2010,40(6). |
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| Authors: | WANG De-chuan YU De-chao ZHOU Xiao-yuan |
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| Affiliation: | WANG De-chuan; YU De-chao; ZHOU Xiao-yuan(Organic Chemistry Department; China Pharmaceutical University; Nanjing 211198; China); |
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| Abstract: | 2-Hydroxy-4-methoxybenzophenone(UV-9) was synthesized from 2,4-dihydroxybenzophenone(UV-0) and dimethyl carbonate(DMC) under microwave.The orthogonal test method was adopted to explore the influences of various factors on the yield of UV-9.The structure of UV-9 was characterized by IR,1H NMR and MS.The statistical package for the social science(SPSS) was used to process the experimental data and the optimum reaction conditions were determined.Compared with the conventional heating reaction,microwave reduced... |
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| Keywords: | microwave synthesis 2 4-dihydroxybenzophenone dimethyl carbonate 2-hydroxy-4-methoxybenzophenone |
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