| 吡唑醚菌酯的主要中间体N-甲氧基-N-2-甲基苯基氨基甲酸甲酯的合成工艺改进 |
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| 引用本文： | 洪湖,马海军,曹庆亮.吡唑醚菌酯的主要中间体N-甲氧基-N-2-甲基苯基氨基甲酸甲酯的合成工艺改进[J].世界农药,2013,35(3):32-33,46. |
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| 作者姓名： | 洪湖 马海军 曹庆亮 |
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| 作者单位： | 1. 无锡禾美农化科技有限公司,江阴,214432
2. 江苏省农药研究所股份有限公司,南京210046;江苏南方农药研究中心,南京210046 |
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| 摘 要： | 介绍了以邻硝基甲苯为起始原料,经锌粉还原法制备吡唑醚菌酯的主要中间体N-甲氧基-N-2-甲基苯基氨基甲酸甲酯的工艺改进。重点解决了邻甲基苯基羟胺不稳定问题,3步总收率达到69%,纯度超过98%。
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| 关 键 词： | 吡唑醚菌酯 中间体 N-甲氧基-N-2-甲基苯基氨基甲酸甲酯 合成 工艺改进 |
Synthesis Improvement of Methyl N-methoxyl-N-2-methylphenylcarbamate |
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| HONG Hu
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MA Hai-jun
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CAO Qing-liang.Synthesis Improvement of Methyl N-methoxyl-N-2-methylphenylcarbamate[J].World Pesticides,2013,35(3):32-33,46. |
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| Authors: | HONG Hu MA Hai-jun CAO Qing-liang |
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| Affiliation: | 1 Wuxi Hemei Agro-chemical Technology Co.,Ltd., Jiangyin 214432,China; 2 Jiangsu Pesticide Research Institute Co., Ltd., Nanjing 210046, China; 3 Jiangsu Southern Pesticide Research Center, Nanjing 210046, China) |
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| Abstract: | A synthesis method of the key intermediate of pyraclostrobin, methyl N-methoxyl-N-2-methylphenylcarbamate by using o-nitrotoluene as raw materials and zinc powder as the reducing agent was improved. The total yield was more than 69% based on o-nitrotoluene, and the purity was higher than 98%. |
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| Keywords: | pyraclostrobin intermediate methyl N-methoxyl-N-2-methylphenylcarbamate synthesis process improvement |
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