阿维菌素类杀虫剂与配体门控离子通道相互作用研究进展

介绍了受体对药物的选择性结合与受体中存在的一些关键位点的氨基酸残基有很大关系。氨基酸残基在通道内排成一个装满水的口袋似的结构，这个口袋结构充当着药物与哺乳类GABAA受体和甘氨酸受体的结合位点。阿维菌素的主要作用靶标谷氨酸门控氯离子通道与这两类受体具有密切的关系，因此，可推测阿维菌素与受体的作用方式也有相类似的模式。这对创制新的具有安全、高活性、高选择性的杀虫剂有重要意义。

Research Progress on the Interaction Between Avermectins and Ligand-gated Ion Channels

The paper mainly presented the importance to drug binding of amino acid residues predicted to line a water-filled pocket in the channel domain.This pocket acts as the binding site for anaesthetics and other modulators of mammalian GABAA and glycine receptors,suggesting similarities in the mode of action between these drugs and the avermectins/ milbemycins.This finding is of great significance in creating new safer pesticides with high activity and selectivity.