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Notch Signaling Regulation in Autoinflammatory Diseases
Authors:Rossella Gratton  Paola Maura Tricarico  Adamo Pio d&#x;Adamo  Anna Monica Bianco  Ronald Moura  Almerinda Agrelli  Lucas Brando  Luisa Zupin  Sergio Crovella
Affiliation:1.Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, Italy; (R.G.); (A.P.d.); (A.M.B.); (R.M.); (L.B.); (L.Z.);2.Department of Medical Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy;3.Department of Pathology, Federal University of Pernambuco, Recife 50670-901, Brazil;4.Department of Biological and Environmental Sciences, College of Arts and Sciences, University of Qatar, Doha 2713, Qatar;
Abstract:Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders.
Keywords:Notch pathway  autoinflammation  genetic  autoinflammatory diseases
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