Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade |
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| Authors: | Md Saifur Rahman Md Badrul Alam Young Kyun Kim Mst Hur Madina Ismail Fliss Sang Han Lee Jin Cheol Yoo |
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| Affiliation: | 1.Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 501-759, Korea; (M.S.R.); (Y.K.K.);2.Department of Food Science, Faculty of Agriculture and Food Sciences, Laval University, Québec, QC G1V 0A6, Canada;3.Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Korea;4.Department of Phytology, Faculty of Agriculture and Food Sciences, Laval University, Québec, QC G1V 0A6, Canada; |
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| Abstract: | In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE2) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent. |
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| Keywords: | anti-inflammation YD1 peptide drug NF-κ B RAW 264 7 TLR-4 MyD88 AKT |
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