Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution |
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| Authors: | P Marizza M Abrami S S Keller P Posocco E Laurini K Goswami |
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| Affiliation: | 1. Department of Micro- and Nanotechnology, Technical University of Denmark (DTU), Lyngby, Denmark;2. Department of Life Sciences, Cattinara Hospital, University of Trieste, Trieste, Italy;3. Department of Engineering and Architecture, University of Trieste, Trieste, Italy,;4. Department of Chemical and Biochemical Engineering, Technical University of Denmark (DTU), Lyngby, Denmark |
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| Abstract: | Hydrogels of poly(n-vinyl-2-pyrrolidone) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as initiator. The mechanical and the nanostructural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LF-NMR), and small angle X-ray scattering. Different irradiation doses as well as polymer and initiator concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LF-NMR dataset of polymer solutions and networks. |
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| Keywords: | Hydrogels drug delivery photocrosslinking polymer network morphology NMR rheology modeling |
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