Chitosan/poly(dimethylaminoethylmethacrylate-co-hydroxyethylacrylate) based semi-IPN hydrogels and silver nanocomposites: Synthesis,evaluation of amoxicillin release studies,and antibacterial studies |
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| Authors: | N Sivagangi Reddy S Eswaramma Ildoo Chung P Ramesh A Chandra Sekhar |
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| Affiliation: | 1. Polymer Biomaterial Design and Synthesis Laboratory, Department of Chemistry, Yogi Vemana University, Kadapa, India;2. Advanced Nanomaterials Lab, Department of Polymer Science and Engineering, Pusan National University, Busan, South Korea;3. Advanced Nanomaterials Lab, Department of Polymer Science and Engineering, Pusan National University, Busan, South Korea;4. Department of Biotechnology, Yogi Vemana University, Kadapa, India |
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| Abstract: | To fabricate new smart materials that can deliver both the pharmaceutically active molecules and metal nanoparticles, we have formulated chitosan-based semi-IPN hydrogels and their silver nanocomposites (Ag NCs) along with amoxicillin (AMX). Semi-IPN hydrogels and their Ag NCs were synthesized from chitosan, dimethylamino ethyl methacrylate and 2-hydroxyethyl methacrylate via simple-free radical polymerization method and reducing with NaBH4. The resultant formulations were evaluated for in vitro release of AMX, anti-bacterial studies and DNA cleavage studies. The hydrogels with AMX-derived silver nanoparticles (Ag NPs) show better ability to cleave DNA and anti-microbial activity than individual AMX and Ag NPs. |
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| Keywords: | Antibacterial studies DNA cleavage drug delivery hydrogels Semi-IPNs silver nanocomposites |
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