| 丙烯酸法合成5,7-二氯-4-氧代-2,3-二氢喹啉 |
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| 引用本文： | 王继凤,陈宏博,郑姝.丙烯酸法合成5,7-二氯-4-氧代-2,3-二氢喹啉[J].农药,2006,45(12):815-817. |
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| 作者姓名： | 王继凤 陈宏博 郑姝 |
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| 作者单位： | 大连理工大学,化工学院化学系,辽宁,大连,116012 |
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| 摘 要： | 5，7-二氯-4-氧代-2，3-二氢喹啉是合成4，5，7-三氯喹啉的重要中间物质，介绍了以丙烯酸和3，5-二氯苯胺为原料合成5,7-二氧-4-氧代-2，3-二氢喹啉，以水为溶剂，室温下搅拌混合物得到加成产物3-（3，5-二氯苯胺）丙酸，经过成环后得到5，7-二氯-4-氧代-2，3-二氢喹啉，产品收率达到85％。
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| 关 键 词： | 5 7-二氯-4-氧代-2 3-二氢喹啉 丙烯酸 4 5 7-三氯喹啉 |
| 文章编号： | 1006-0413（2006）12-0815-03 |
| 收稿时间： | 2006-05-31 |
| 修稿时间： | 2006-05-312006-06-28 |
Synthesis of 5,7-dichloro-2,3-dihydroquinolin-4-(1 H)-one through acrylic acid |
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| WANG Ji-feng,CHEN Hong-bo,ZHENG Shu.Synthesis of 5,7-dichloro-2,3-dihydroquinolin-4-(1 H)-one through acrylic acid[J].Pesticides,2006,45(12):815-817. |
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| Authors: | WANG Ji-feng CHEN Hong-bo ZHENG Shu |
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| Affiliation: | Chemistry Department, Dalian University of Technology, Dalian 116012, Liaoning, China |
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| Abstract: | 5,7-Dichloro-2,3-dihydroquinolin-4-(1H)-one is an important intermediate for the synthesis of 4,5,7-trichloroquinoline, which can be synthesized from 3,5-dichloroaniline and acrylic acid. The obtained condensa-tion 3-(3,5-dichloroanilino)-propionic acid via cyclization in polyphosphoric acid for 3 hours to give 5,7-dichloro-2,3-dihydroquinolin-4-(1H)-one, yield 85%. |
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| Keywords: | 5 7-dichloro-2 3-dihydroquinolin-4-(1H)-one acrylic acid 4 5 7-trichloroquinoline |
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