| 不同取代度磺丁基醚-β-环糊精的合成工艺研究 |
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| 引用本文： | 杨学敏,杨波,廖霞俐,肖丹,易东,秦启学.不同取代度磺丁基醚-β-环糊精的合成工艺研究[J].化学世界,2013,54(2):110-113. |
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| 作者姓名： | 杨学敏 杨波 廖霞俐 肖丹 易东 秦启学 |
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| 作者单位： | 昆明理工大学生命科学与技术学院药学与制药工程技术中心,云南昆明,650500 |
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| 摘 要： | 研究了不同取代度磺丁基醚-β-环糊精的合成。选用1,4-磺丁基内酯为原料,以氢氧化钠水溶液为溶剂,通过正交实验考察反应时间、反应温度、β-环糊精和1,4-磺丁基内酯摩尔比、氢氧化钠的量等因素对产物平均取代度的影响。采用MS和1 H NMR对产物结构进行了表征。
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| 关 键 词： | β-环糊精 磺丁基醚-β-环糊精 取代度 |
Study on the Synthesis Technology of Sulfobutyl Ether β-Cyclodextrins with Different of Substitution |
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| YANG Xue-min,YANG Bo,LIAO Xia-li,XIAO Dan,YI Dong,QIN Qi-xue.Study on the Synthesis Technology of Sulfobutyl Ether β-Cyclodextrins with Different of Substitution[J].Chemical World,2013,54(2):110-113. |
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| Authors: | YANG Xue-min YANG Bo LIAO Xia-li XIAO Dan YI Dong QIN Qi-xue |
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| Affiliation: | (Life Science and Biotechnology of Kunming University of Science and Technology Drug Synthesis Chemistry Laboratory,Yunnan Kunming 650500,China) |
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| Abstract: | Sulfobutyl ether β-cyclodextrins of different degrees of substitution of were prepared.β-Cyclodextrin and 1,4-sulfonylurea butyl lactone were reacted in NaOH solution.The influences of factors including reaction time and temperature,molar ratio of β-cyclodextrin to 1,4-sulfonylurea butyl lactone and dosage of NaOH on the average substitution degree of sulfobutyl ether β-cyclodextrins were studied via orthogonal experiments.Furthermore,the structures of sulfobutyl ether β-cyclodextrins were characterized by MS and 1H NMR,respectively. |
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| Keywords: | β-cyclodextrin sulfobutyl ether β-cyclodextrins substitution degree |
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