| DL-丝氨酸的合成工艺改进 |
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| 引用本文： | 陈绘如,赵欢迎,庞宝华,张雷,马荣荣.DL-丝氨酸的合成工艺改进[J].化学试剂,2012,34(8):766-768. |
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| 作者姓名： | 陈绘如 赵欢迎 庞宝华 张雷 马荣荣 |
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| 作者单位： | 1. 常州工程职业技术学院制药系,江苏常州,213164
2. 张家港华昌药业有限公司,江苏苏州,215600 |
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| 基金项目： | 江苏省高等学校大学生实践创新项目 |
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| 摘 要： | 以亚甲氨基乙腈与多聚甲醛为原料,经亲核加成和水解两步反应合成DL-丝氨酸,总收率73.2%。考察了多聚甲醛用量、4-二甲氨基吡啶用量、三乙胺用量、反应时间、反应温度等因素对亲核加成反应的影响。目标产物经熔点、IR进行结构确认。
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| 关 键 词： | DL-丝氨酸 合成 亲核加成 4-二甲氨基吡啶 |
Improvement in synthesis of DL-serine |
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| CHEN Hui-ru
,
ZHAO Huan-ying
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PANG Bao-hua
,
ZHANG Lei
,
MA Rong-rong.Improvement in synthesis of DL-serine[J].Chemical Reagents,2012,34(8):766-768. |
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| Authors: | CHEN Hui-ru ZHAO Huan-ying PANG Bao-hua ZHANG Lei MA Rong-rong |
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| Affiliation: | 1(1.Department of Pharmaceutical,Changzhou Institute of Engineering Technology,Changzhou 213164,China;2.Zhangjiagang Huachang Pharmaceutical Co.,Ltd.,Suzhou 215600,China) |
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| Abstract: | DL-Serine was synthesized from n-methylene-glycinonitrile and paraformaldehyde via two steps reaction of nucleophilic addition and hydrolysis with an overall yield of 73.2%.The factors on the reaction of nucleophilic addition,such as the dosage of paraformaldehyde,4-dimethylamiopryidine and triethylamine,the reaction temperature and the reaction time,had been investigated.The structures of the compounds were confirmed by melting point measurements and IR. |
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| Keywords: | DL-serine synthesis nucleophilic addition 4-dimethylamiopryidine |
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