| 高压静电抗溶剂法制备聚乳酸微球 |
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| 引用本文： | 陈爱政,杨月梅,王士斌,孙晴晴,刘源岗,党婷婷.高压静电抗溶剂法制备聚乳酸微球[J].化工进展,2012,31(9):2024-2030. |
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| 作者姓名： | 陈爱政 杨月梅 王士斌 孙晴晴 刘源岗 党婷婷 |
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| 作者单位： | 1. 华侨大学化工学院,福建厦门361021 华侨大学生物材料与组织工程研究所,福建厦门361021
2. 华侨大学化工学院,福建厦门,361021 |
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| 基金项目： | 国家自然科学基金，福建省自然科学基金(2010J05027 2011J01223)项目 |
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| 摘 要： | 以无水乙醇为非溶剂,采用高压静电抗溶剂法制备聚乳酸微球。通过24全因子试验设计对微球粒径和粒径分布的影响因素进行了显著性分析。并考察最显著因素对微球表面形貌的影响规律。结果表明,推进速度是影响微球粒径的最显著因素,最优条件下微球表面光滑、球形度好,粒径分布窄。浓度为3%,相对分子质量为5万～10万的聚乳酸制备的微球,球形度较好。经过高压静电处理后,傅里叶红外光谱测定表明聚乳酸无明显结构摄动;X射线粉末衍射分析表明聚乳酸晶体结构未发生明显变化。
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| 关 键 词： | 高压静电体系 抗溶剂 聚乳酸 因子试验 |
Development of poly （L-lactide） microspheres in high-voltage electrostatic antisolvent process |
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| CHEN Aizheng,YANGYuemei,WANG Shibin,SUN Qingqing,LIU Yuangang,DANG Tingting.Development of poly （L-lactide） microspheres in high-voltage electrostatic antisolvent process[J].Chemical Industry and Engineering Progress,2012,31(9):2024-2030. |
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| Authors: | CHEN Aizheng YANGYuemei WANG Shibin SUN Qingqing LIU Yuangang DANG Tingting |
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| Affiliation: | 1(1School of Chemical Engineering,Huaqiao University,Xiamen 361021,Fujian,China;2Institute of Biomaterials and Tissue Engineering,Huaqiao University,Xiamen 361021,Fujian,China) |
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| Abstract: | An antisolvent,absolute ethyl alcohol was used in the high-voltage electrostatic antisolvent process to prepare poly(L-lactide) microspheres.A 24 factorial experiment was designed to investigate and identify the relative significance of the processing parameters on particle size and particle size distribution of the products.The results indicated that the effect of push speed was dominant in the results regarding particle size.After optimization,the resulting poly(L-lactide) microspheres exhibited good spherical shape,smooth surface and narrow particle size distribution.When the concentration and molecular weight of poly(L-lactide) were 3%(w/v) and 50～100 kDa respectively,the resulting microspheres showed good spherical shape.Fourier transform infrared(FTIR) spectroscopy measurement found no significant structural perturbation.X-ray powder diffraction(XRPD) analysis revealed no significant crystal structural changes. |
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| Keywords: | high-voltage eletrostatic system anti-solvent poly(L-Lactide) factorial experiment |
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