Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages |
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| Authors: | Hiromi Nabeshi Tomoaki Yoshikawa Akihiro Arimori Tokuyuki Yoshida Saeko Tochigi Toshiro Hirai Takanori Akase Kazuya Nagano Yasuhiro Abe Haruhiko Kamada Shin-ichi Tsunoda Norio Itoh Yasuo Yoshioka Yasuo Tsutsumi |
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| Affiliation: | 1. Solid State Electronics Department and CeNIDE, University of Duisburg-Essen, Lotharstr. 55, 47048, Duisburg, Germany
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| Abstract: | In this study, complexes composed of poly-l-tyrosine (pLT) and single-walled carbon nanotubes (SWCNTs) were produced and the dispersibility of the pLT/SWCNT complexes in water by measuring the ζ potential of the complexes and the turbidity of the solution were investigated. It is found that the absolute value of the ζ potential of the pLT/SWCNT complexes is as high as that of SWCNTs modified with double-stranded DNA (dsDNA) and that the complexes remain stably dispersed in the water at least for two weeks. Thermogravimetry analysis (TGA) and visualization of the surface structures of pLT/SWCNT complexes using an atomic force microscope (AFM) were also carried out. |
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