| 复相乳化法制备聚乳酸微胶囊及其性能考察 |
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| 引用本文： | 姚文彬,杨月梅,王士斌,刘源岗,毛鸿浩.复相乳化法制备聚乳酸微胶囊及其性能考察[J].广东化工,2010,37(7):3-4,7. |
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| 作者姓名： | 姚文彬 杨月梅 王士斌 刘源岗 毛鸿浩 |
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| 作者单位： | 1. 华侨大学,化工学院,生物系,福建,厦门,361021
2. 华侨大学,化工学院,生物系,福建,厦门,361021;华侨大学,制药工程研究所,福建,厦门,361021 |
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| 基金项目： | 国家"863"计划项目，国家自然科学基金资助项目，福建省自然科学基金资助项目 |
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| 摘 要： | 采用W/O/W复乳-溶剂蒸发法制备聚乳酸微球得到的最优制备条件:油水相比例5︰2、卡培他滨浓度为1.0mg/mL、外水相药液浓度5.0mg/mL,外水相体积20mL,几丁聚糖浓度为0.50%。以抗癌药卡培他滨为模型,考察了几丁聚糖浓度对聚乳酸微胶囊缓释性能的影响。结果表明:随着几丁聚糖浓度的增加,微囊释放速率相应降低。
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| 关 键 词： | 缓释 微胶囊 卡培他滨 聚乳酸 |
Preparation and Release Efficiency of Polylactic Acid Microspheres |
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| Yao Wenbin,Yang Yuemei,Wang Shibin,Liu Yuangang,Mao Honghao.Preparation and Release Efficiency of Polylactic Acid Microspheres[J].Guangdong Chemical Industry,2010,37(7):3-4,7. |
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| Authors: | Yao Wenbin Yang Yuemei Wang Shibin Liu Yuangang Mao Honghao |
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| Affiliation: | 1. Department of Biology, College of Chemical Engineering, Huaqiao University, Xiamen 361021 ; 2. Research Center of Pharmaceutical Engineering, Xiamen 361021, China) |
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| Abstract: | Capecitabine-PLGA microsphcres were prepared by double emulsion method. A series of preparation factors were optimized as followed：O/W 5：2, 1 mg/mL capecitabinc, 5 mg/mL capecitabine of external aqueous phase, 20 mL volume of external aqueous phase, 0.5 % concentration of chitosan. Anticancer drug capecitabine was taken as the model to investigate the influence of concentration of chitosan to show the release characteristics of the microcapsule. The result indicated that with the concentration of chitosan increasing, the microcapsulc release properties decreased. |
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| Keywords: | controlled-release microcapsule capecitabinc PLGA |
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