| 2-氯-6，7-二氢喹啉-8（5H）-酮的合成研究 |
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| 引用本文： | 邱仓柏,莫卫民.2-氯-6，7-二氢喹啉-8（5H）-酮的合成研究[J].广东化工,2011(8):3+28-3,28. |
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| 作者姓名： | 邱仓柏 莫卫民 |
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| 作者单位： | 浙江工业大学化学工程与材料学院; |
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| 基金项目： | 国家自然科学基金资助项目(20876149) |
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| 摘 要： | 2-氯-6，7-二氢喹啉培（5H）-酮是四氢喹啉是一个重要的含氮杂环化合物。文章以2-氯-5，6，7，8-四氢喹啉为原料，经氧化、酯化、水解反应后得到2．氯-5，6，7，8-四氢喹啉-8-醇，再经Anelli氧化后得到总收率为57，8％的目标产物。所得化合物的结构均经核磁和质谱确证。
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| 关 键 词： | 2-氯．6 7-二氢喹啉．8（5H）-酮 2-氯-5 ，6， 7， 8-四氢喹啉 2-氯-5 ，6， 7， 8-四氢喹啉-8- 醇 Anelli氧化 |
Study on the Synthesis of 2-chloro-6,7-dihydroquinolin-8(5H)-one |
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| Qiu Cangbai,Mo Weimin.Study on the Synthesis of 2-chloro-6,7-dihydroquinolin-8(5H)-one[J].Guangdong Chemical Industry,2011(8):3+28-3,28. |
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| Authors: | Qiu Cangbai Mo Weimin |
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| Affiliation: | Qiu Cangbai,Mo Weimin(College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | 2-Chloro-6,7-dihydroquinolin-8(5H)-one is an important nitrogen-containing heterocycle compound.2-Chloro-5,6,7,8-tetrahydroquinoline was used as the raw material,and 2-chloro-5,6,7,8-tetrahydroquinolin-8-ol was synthesized via oxidation,esterification and hydrolyzation.After anelli oxidation of,2-chloro-6,7-dihydroquinolin-8(5H)-one was synthesized in 57.8 % total yield.The structures of the obtained compounds were characterized by NMR and MS. |
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| Keywords: | 2-chloro-6 7-dihydroquinolin-8(5H)-one 2-chloro-5 6 7 8-tetrahydroquinoline 8-tetrahydroquinolin-8-ol Anelli oxidation |
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