| 盐酸安非他酮的合成研究 |
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| 引用本文： | 夏闽,徐宝峰.盐酸安非他酮的合成研究[J].山东化工,2003,32(3):3-5. |
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| 作者姓名： | 夏闽 徐宝峰 |
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| 作者单位： | 临沂师范学院化学与环境科学系 山东临沂276005
(夏闽)，临沂师范学院化学与环境科学系 山东临沂276005(徐宝峰) |
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| 摘 要： | 盐酸安非他酮为一种抗抑郁药物。以间氯苯基乙酮为原料 ,经溴代 ,N -烃基化反应得盐酸安非他酮。在溴化反应中采用新型溴试剂 ,避免了直接溴代 ,溴代产率提高至 85 %。在N -烃基化反应中使用聚乙二醇作相转移剂 ,得到高产率产物 ,结构经IR ,1 HNMR和元素分析确证
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| 关 键 词： | 盐酸安非他酮 溴试剂 相转移催化 合成 |
Study on Synthesis of the Amfebutamone Hydrochloride |
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| XIA Min,XU Bao-feng.Study on Synthesis of the Amfebutamone Hydrochloride[J].Shandong Chemical Industry,2003,32(3):3-5. |
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| Authors: | XIA Min XU Bao-feng |
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| Abstract: | Amfebutamone hydrochloride is an antidepressant.1-(3-chlorophenyl)-1-propanone takes for raw material.After through brominating,N-alkylation,the amfebutamone hydrochloride was obtained.A new bromizating agent was used in the brominating reaction.Immediate brominating was averted.The yield was over 85%.Polyethylene glycol(PEG)took for phase-transfer catalyst(PTC) in the N-alkylation reaction which good yields.The structures of the products were determined by IR, 1HNMR and elemental analysis. |
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| Keywords: | amfebatamone hydrochlorid brominating agent phase-transfer catalysis synthesis |
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