呈味核苷酸二钠结晶工艺研究

呈昧核苷酸二钠包括5’-肌苷酸二钠和5’-鸟苷酸二钠，难以形成良好的结晶体，针对现有研究中存在的问题。对呈味核苷酸二钠结晶工艺进行改进，优化工艺参数。研究发现，采用乙醇为溶析剂，在合适的结晶液浓度和溶析剂添加量的条件下，添加晶种程序降温结晶，有利于提高结晶收率、产品纯度和堆密度。在优化的结晶条件下，呈味核苷酸二钠产品色谱纯度达到99．54％，堆密度达到0．54g/cm3，满足国际市场的要求。

Study on Crystallization Process of Disodium 5'-Ribonucleotide

Disodium 5'-Ribonucleotide composed of disodium 5'-inosinate and disodium 5'-guanylate.The improvement on the crystalline technique of disodium 5'-ribonucleotide was reported. Crystallizationsolvent was ethanol. Under a suitable condition of crystallization, the seed crystal was helpful to improvethe crystallization yield, product purity and bulk density. Under the optimized conditions, the productcould be obtained with purity of 99.54%, the bulk density was 0.54 g/cm3. The quality achieved theinternational...