Epoxide-diol pathway in the metabolism of 5H-dibenzo[b,f]-azepine (iminostilbene)

5H-Dibenzolb,f]azepine-10,11-epoxide and 10,11-dihydro-10,11-dihydroxy-5H-dibenzob,f]azepine were identified by gas chromatography-mass spectrometry in rat urine as the main biotransformation products in the metabolism of 5H-dibenzob,f]azepine (iminostilbene). The presence of these metabolites was confirmed in vitro by incubating iminostilbene with rat liver microsomal enzymes.