Reproducible and Sensitive Plasmonic Sensing Platforms Based on Au-Nanoparticle-Internalized Nanodimpled Substrates |
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Authors: | Hajun Dang Sung-Gyu Park Yixuan Wu Namhyun Choi Jun-Yeong Yang Seunghun Lee Sang-Woo Joo Lingxin Chen Jaebum Choo |
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Affiliation: | 1. Department of Chemistry, Chung-Ang University, Seoul, 06974 South Korea;2. Nano-Bio Convergence Department, Korea Institute of Materials Science (KIMS), Changwon, 51508 South Korea;3. Department of Chemistry, Soongsil University, Seoul, 06978 South Korea;4. Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003 China |
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Abstract: | Electromagnetic enhancement effects through localized surface plasmon resonance considerably amplify the intensity of incident light when molecules are positioned in the vicinity of miniscule nanogaps. The aggregation of plasmonic nanoparticles synthesized using bottom-up methods has been extensively used to generate hot spots in solutions. These methods assist in obtaining non-periodic plasmonic signals, because the realization of uniform nanogaps through particle aggregation is difficult. Nanostructured substrates with gaps of 20–100 nm have also been fabricated using the top-down approach. However, the fabrication of smaller nanogap templates using these methods is difficult owing to high costs and low throughput. Therefore, a nanodimple array internalized with AuNPs is developed in this study to mitigate the challenges encountered in the bottom-up and top-down approaches. Precise nanogaps are generated by regularly internalizing AuNPs in the cavities of nanodimples through DNA hybridization. Simulations of the electric field distribution indicate that the incorporation of 80 nm-sized AuNPs into a curved nanodimpled Au substrate generate high-density volumetric hot spots within a detection volume, and result in a high plasmonic enhancement factor of 8.25 × 107. The tremendous potential of the proposed plasmonic platform as an SERS-based biomedical diagnostic device is also verified. |
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Keywords: | electromagnetic enhancement nanodimpled substrate nanogaps plasmonic coupling surface-enhanced Raman scattering |
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