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Mimic Drug Dosage Modulation for Neuroplasticity Based on Charge-Trap Layered Electronics |
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| Authors: | Caifang Gao Mu-Pai Lee Mengjiao Li Ko-Chun Lee Feng-Shou Yang Che-Yi Lin Kenji Watanabe Takashi Taniguchi Po-Wen Chiu Chen-Hsin Lien Wen-Wei Wu Shu-Ping Lin Wenwu Li Yen-Fu Lin Junhao Chu |
| Affiliation: | 1. Engineering Research Center for Nanophotonics & Advanced Instrument (MOE), Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai), School of Physics and Electronic Science, East China Normal University, Shanghai, 200241 China
Department of Physics, National Chung Hsing University, Taichung, 40227 Taiwan;2. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300 Taiwan Department of Physics, National Chung Hsing University, Taichung, 40227 Taiwan;3. Department of Physics, National Chung Hsing University, Taichung, 40227 Taiwan;4. Department of Physics, National Chung Hsing University, Taichung, 40227 Taiwan Department of Electrical Engineering & Institute of Electronic Engineering, National Tsing Hua University, Hsinchu, 300 Taiwan;5. National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, 305-0044 Japan;6. Department of Electrical Engineering & Institute of Electronic Engineering, National Tsing Hua University, Hsinchu, 300 Taiwan;7. Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300 Taiwan Center for the Intelligent Semiconductor Nano-system Technology Research, National Chiao Tung University, Hsinchu, 300 Taiwan;8. Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 40227 Taiwan;9. Engineering Research Center for Nanophotonics & Advanced Instrument (MOE), Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai), School of Physics and Electronic Science, East China Normal University, Shanghai, 200241 China;10. Engineering Research Center for Nanophotonics & Advanced Instrument (MOE), Technical Center for Multifunctional Magneto-Optical Spectroscopy (Shanghai), School of Physics and Electronic Science, East China Normal University, Shanghai, 200241 China Institute for Optoelectronics, Shanghai Institute of Intelligent Electronics and Systems, Fudan University, Shanghai, 200433 China |
| Abstract: | The human brain is often likened to an incredibly complex and intricate computer, rather than electrical devices, consisting of billions of neuronal cells connected by synapses. Different brain circuits are responsible for coordinating and performing specific functions. The reward pathway of the synaptic plasticity in the brain is strongly related to the features of both drug addiction and relief. In the current study, a synaptic device based on layered hafnium disulfide (HfS2) is developed for the first time, to emulate the behavioral mechanisms of drug dosage modulation for neuroplasticity. A strong gate-dependent persistent photocurrent is observed, arising from the modulation of substrate-trapping events. By controlling the polarity of gate voltage, the basic functions of biological synapses are realized under a range of light spiking conditions. Furthermore, under the control of detrapping/trapping events at the HfS2/SiO2 interface, positive/negative correlations of the An/A1 index, which significantly reflected the weight change of synaptic plasticity, are realized under the same stimulation conditions for the emulation of the drug-related addition/relief behaviors in the brain. The findings provide a new advance for mimicking human brain plasticity. |
| Keywords: | charge trapping drug addiction gate-dependent modulations layered HfS2 synaptic device neuroplasticity |
