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| 两面针红外指纹图谱与抗癌活性的谱效研究 | |
| 引用本文： | 毛晓丽,覃禹,蔡鹃,郑娟梅,叶月华,刘华钢,黄庶识.两面针红外指纹图谱与抗癌活性的谱效研究[J].红外与毫米波学报,2013,32(1):91-96. |
| 作者姓名： | 毛晓丽 覃禹 蔡鹃 郑娟梅 叶月华 刘华钢 黄庶识 |
| 作者单位： | 毛晓丽:广西科学院生物物理实验室, 广西 南宁 530007广西柳州市人民医院药剂科, 广西 柳州 545006 覃禹:广西柳州市人民医院药剂科, 广西 柳州 545006 蔡鹃:广西科学院生物物理实验室, 广西 南宁 530007广西中医学院药学院, 广西 南宁 530001 郑娟梅:广西区食品药品检验所中药室, 广西 南宁 530021 叶月华:广西区食品药品检验所中药室, 广西 南宁 530021 刘华钢:广西医科大学药学院, 广西 南宁 530021 黄庶识:广西科学院生物物理实验室, 广西 南宁 530007 |
| 基金项目： | 国家自然科学基金(30760302), 广西科学研究与技术开发计划项目资助(0992003A-20, 0992003A-21) |
| 摘 要： | 研究两面针的红外指纹图谱与抗肿瘤活性之间的相互关系.基于不同产地的两面针氯仿提取物的红外指纹图谱特征峰强度及其抗肿瘤活性的效果,采用后退法构建以两面针抑制人胃腺癌7901和人宫颈癌Hela两种肿瘤细胞株的谱效模型.所建立数学模型的预测值与实际测量值的偏差率全部在10%以内,说明两面针红外指纹图谱和两面针抗肿瘤活性之间具有相关性.结果表明,生物碱类成分在两面针抗肿瘤药效活性中发挥了重要的作用. |
| 关 键 词： | 光谱分析 两面针 红外指纹图谱 谱效关系 |
| 收稿时间： | 2011/11/5 |
| 修稿时间： | 2011/12/28 0:00:00 |
Infrared fingerprint of Zathoxylum nitidum and its effect on inhibition of tumor cell |
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| MAO Xiao-Li,QIN Yu,CAI Juan,ZHENG Juan-Mei,YE Yue-Hu,LIU Hua-Gang and HUANG Shu-Shi.Infrared fingerprint of Zathoxylum nitidum and its effect on inhibition of tumor cell[J].Journal of Infrared and Millimeter Waves,2013,32(1):91-96. | |
| Authors: | MAO Xiao-Li QIN Yu CAI Juan ZHENG Juan-Mei YE Yue-Hu LIU Hua-Gang and HUANG Shu-Shi |
| Affiliation: | 1(1.Biophysics Laboratory,Guangxi Academy of Sciences,Nanning 530007,China; 2.Depart.of Pharmacy,Guangxi Liuzhou People’s Hospital,Liuzhou 545006,China; 3.Depart.of Pharmacology,Guangxi University of Chinese Medicine,Nanning 530001,China; 4.School of Pharmaceutical Sciences,Guangxi Medical University,Nanning 530021,China; 5.Depart.of Traditional Chinese Medicine,Guangxi Institute for Food and Drug Control,Nanning 530021,China) |
| Abstract: | Mathematical expression was established for evaluating anticancer efficacy of samples of Z. nitidum to human tumor cells based on their infrared fingerprints. Chloroform extracts of the root of Z. nitidum from different habitats in China were used as subject samples to do anticancer experiments on two strains of human tumor cells, 7901 and Hela cells. Meanwhile, their fingerprints of infrared spectra were obtained. Screening arguments of backward elimination method was adopted to establish the spectra-effect correlation between infrared fingerprint and pharmacology data. The results showed that deviations of the predictive values from the true values were within ±10% for the two kinds of tumor cells, suggested that there was close correlation between infrared fingerprint and biological activity of Z. nitidum. The model implied that alkaloids in Z. nitidum have main effect on tumor cells. |
| Keywords: | spectral analysis Zanthoxylum nitidum(Roxb ) DC infrared fingerprint spectrum-effect relationships |
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